Endocrine Abstracts

Case: A 51-year-old-woman was referred to endocrinology outpatient clinic due to a thyroid nodule 9 mm in diameter. Fine needle aspiration (FNA) biopsy revealed papillary thyroid carcinoma and she was directed to surgery. The surgeon decided to perform subtotal thyroidectomy due to the small nodule size. Pathologic examination showed the histology to be consistent with tall cell carcinoma. Complementary total thyroidectomy was proposed to the patient but she did not accept the...

Background and aims: Hypovitaminosis D may be associated with metabolic parameters in addition to its well-known calcemic actions. There is increasing evidence that vitamin D metabolism affects the risk of insulin resistance although the underlying molecular mechanism of this association is not clear but on the basis of evidence it is not clear whether or not vitamin D supplementation therapy in vitamin D-deficient prediabetics affects the prevention of type 2 diabetes. Our st...

Objective: Recent recommendations suggest that HbA1c as a stable and standardised index of chronic glucose exposure over time and could be used as a better biochemical marker for the diagnosis of diabetes and prediabetes. Our aim in this cross-sectional study is to assess the validity of HbA1c as a screening tool for the detection of prediabetes in our patient population.Methods: The study was done in 265 patients selected among the participants attended...

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

Distant metastases as initial manifestation of follicular thyroid carcinoma is rare. We report a case of an unusual initial presentation of follicular thyroid carcinoma on follow-up. A 52-year-old woman presented with a 12-month history of progressively enlarging mass in the anterior chest wall. The mass was fixed to the chest wall, measuring 12×10 cm in diameter. Computed tomography demonstrated a lobulated soft-tissue mass (17×11×6 cm) destructing sternum and ...

Objective: Platelet activation is a recently recognized characteristic of prolactin, which functions through the potentiation of ADP-induced P-selectin expression on platelets. Studies in hyperprolactinemic patients demonstrated atherosclerotic disorders related to insulin resistance; convenient milieus for platelet activation. To investigate the association between hyperprolactinemia and platelet activation related to P-selectin expression, we studied on hyperprolactinemic an...

Objective: Our aim was to determine the prevalence and clinicopathological characteristics of thyroid cancers in the dialysis population and to evaluate potential risk factors.Design: We performed a retrospective analysis of our end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000–2006). Then we compared the data of thyroid cancer patients on dialysis (n=9) with the data of patients who had hist...

Objective: Approximately 30% of patients with thyroid nodules have indeterminate, nondiagnostic, or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic markers to distinguish benign from malignant thyroid neoplasms, so we focused on G2-M boundary regulators of the cell cycle and investigated the expression of two proteins, cyclin A and cyclin B1.M...